Pharmacokinetics of levetiracetam in neonates with seizures.
نویسندگان
چکیده
The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.
منابع مشابه
Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
PURPOSE The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM. METHODS A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg...
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Background: Seizure is a chronic neurological disease that may have non-neurological origins such as astrocytes and microglia. Objective: The aim of this study was to investigate the effect of alone and co-administration of cabergoline and levetiracetam on the histological and stereological structure of the cerebral cortex, hippocampus and cerebellum following chronic seizures in rat. Methods...
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BACKGROUND Neonatal seizures are associated with neurological sequelae and an increased risk of epilepsy later in life. Phenobarbital and phenytoin remain the antiepileptic drugs (AEDs) most commonly used to treat neonatal seizures, despite their suboptimal effectiveness and safety. As a result, other AEDs, such as levetiracetam and topiramate, are often used in neonates with refractory seizure...
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− Treatment of seizures in pediatric patients is complicated by the fact that the etiology of the disorder and the pharmacokinetics, efficacy, and safety of antiepileptic drugs (AEDs) may differ from that in adults. With few controlled clinical trials of AEDs in children, the selection of agents to treat pediatric patients must be made on the basis of information from small uncontrolled studies...
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ورودعنوان ژورنال:
- The Journal of pediatrics
دوره 159 1 شماره
صفحات -
تاریخ انتشار 2011